No less than twelve former Big West baseball players suited up for Opening Day of the 2025 Major League Baseball (MLB) season. 

Cal State Fullerton led all Big West programs with four players on Opening Day rosters. Big West players are spread out over 13 MLB clubs, with the Cleveland Guardians housing two former players on their rosters. 

Additional players are currently key reserves, prospects or on the injured list of clubs and may join the active roster in the near future. Those include Rob Brantly (UC Riverside/Miami Marlins), J.D. Davis (Cal State Fullerton/Los Angeles Angels), Darius Vines (Cal State Bakersfield/Atlanta Braves), Jeff McNeil (Long Beach State/New York Mets), Shane Bieber (UC Santa Barbara/Cleveland Guardians), Brooks Lee (Cal Poly/Minnesota Twins) and Drew Thorpe (Cal Poly/Chicago White Sox). 

Big West alums are also scattered throught MLB coaching staffs and front offices, but no two are bigger than managers Brandon Hyde (Long Beach State/Baltimore Orioles) and Mark Kotsay (Cal State Fullerton/Oakland A's). 
 

MLB Player, Position	Alma Mater	MLB Club
Tanner Bibee, SP	Cal State Fullerton	Cleveland Guardians
Matt Chapman, 3B	Cal State Fullerton	San Francisco Giants
Jarren Duran, OF	Long Beach State	Boston Red Sox
Robert Garcia, RP	UC Davis	Texas Rangers
Calvin Faucher, RP	UC Irvine	Miami Marlins
Garrett Hampson, UTL	Long Beach State	Arizona Diamondbacks
Christian Koss, IF	UC Irvine	San Francisco Giants
Michael Lorenzen, SP	Cal State Fullerton	Kansas City Royals
Andre Pallante, RP	UC Irvine	St. Louis Cardinals
Joe Ryan, SP	CSUN	Minnesota Twins
Cade Smith, RP	Hawai'i	Cleveland Guardians
Justin Turner, IF	Cal State Fullerton	Chicago Cubs
Bryan Woo, SP	Cal Poly	Seattle Mariners